Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells

Recent studies have shown that microRNAs and long noncoding RNAs (lncRNAs) regulate the expression of drug metabolizing enzymes (DMEs) in human hepatic cells and that a set of DMEs, including UDP glucuronosyltransferase (UGT) 2B15, is down-regulated dramatically in liver cells by toxic acetaminophen...

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Bibliographische Detailangaben
Veröffentlicht in:Drug Metab Dispos
Hauptverfasser: Yu, Dianke, Chen, Jing, Chen, Si, Xu, Lin, Wu, Leihong, Li, Dongying, Luo, Jiao, Jin, Yuan, Zhao, Yanjie, Knox, Bridgett, Tolleson, William H., Wang, Xubing, Guo, Lei, Tong, Weida, Ning, Baitang
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2020
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153565/
https://ncbi.nlm.nih.gov/pubmed/32086297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.090043
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