MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation

Drug metabolizing enzymes mediate biotransformation of drugs and play an essential role in drug efficacy and toxicity. Human sulfotransferases are a superfamily of Phase II detoxification enzymes that metabolize a wide spectrum of endogenous compounds and xenobiotics. SULT2A1 is one of the most abun...

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Publicado no:Biochem Pharmacol
Main Authors: Li, Dongying, Knox, Bridgett, Chen, Si, Wu, Leihong, Tolleson, William H., Liu, Zhichao, Yu, Dianke, Guo, Lei, Tong, Weida, Ning, Baitang
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779501/
https://ncbi.nlm.nih.gov/pubmed/31445882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2019.08.019
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