MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes

Cytochrome P450 2B6 (CYP2B6), mainly expressed in the liver and brain, is important for processing a number of widely used drugs. Variations in CYP2B6 expression are associated with decreased drug efficacy or adverse effects in some patients. Although CYP2B6 genetic variants are associated with its...

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Détails bibliographiques
Publié dans:Biochem Pharmacol
Auteurs principaux: Jin, Yaqiong, Yu, Dianke, Tolleson, William H., Knox, Bridgett, Wang, Yong, Chen, Si, Ren, Zhen, Deng, Helen, Guo, Yongli, Ning, Baitang
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672627/
https://ncbi.nlm.nih.gov/pubmed/27311985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.06.007
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