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The Bateman domain of IMP dehydrogenase is a binding target for dinucleoside polyphosphates
IMP dehydrogenase (IMPDH) is an essential enzyme that catalyzes the rate-limiting step in the de novo guanine nucleotide biosynthetic pathway. Because of its involvement in the control of cell division and proliferation, IMPDH represents a therapeutic for managing several diseases, including microbi...
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| Publicat a: | J Biol Chem |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6779442/ https://ncbi.nlm.nih.gov/pubmed/31416831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC119.010055 |
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