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A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases
Inosine-5′-monophosphate dehydrogenase (IMPDH) is an essential enzyme for nucleotide metabolism and cell proliferation. Despite IMPDH is the target of drugs with antiviral, immunosuppressive and antitumor activities, its physiological mechanisms of regulation remain largely unknown. Using the enzyme...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5454003/ https://ncbi.nlm.nih.gov/pubmed/28572600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02805-x |
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