A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases

Inosine-5′-monophosphate dehydrogenase (IMPDH) is an essential enzyme for nucleotide metabolism and cell proliferation. Despite IMPDH is the target of drugs with antiviral, immunosuppressive and antitumor activities, its physiological mechanisms of regulation remain largely unknown. Using the enzyme...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Buey, Rubén M., Fernández-Justel, David, Marcos-Alcalde, Íñigo, Winter, Graeme, Gómez-Puertas, Paulino, de Pereda, José María, Luis Revuelta, José
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454003/
https://ncbi.nlm.nih.gov/pubmed/28572600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02805-x
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items