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The Bateman domain of IMP dehydrogenase is a binding target for dinucleoside polyphosphates

IMP dehydrogenase (IMPDH) is an essential enzyme that catalyzes the rate-limiting step in the de novo guanine nucleotide biosynthetic pathway. Because of its involvement in the control of cell division and proliferation, IMPDH represents a therapeutic for managing several diseases, including microbi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Fernández-Justel, David, Peláez, Rafael, Revuelta, José Luis, Buey, Rubén M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779442/
https://ncbi.nlm.nih.gov/pubmed/31416831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC119.010055
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