Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases

Inosine-5′-monophosphate dehydrogenase (IMPDH) plays key roles in purine nucleotide metabolism and cell proliferation. Although IMPDH is a widely studied therapeutic target, there is limited information about its physiological regulation. Using Ashbya gossypii as a model, we describe the molecular m...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nat Commun
Autori principali: Buey, Rubén M., Ledesma-Amaro, Rodrigo, Velázquez-Campoy, Adrián, Balsera, Mónica, Chagoyen, Mónica, de Pereda, José M., Revuelta, José L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660370/
https://ncbi.nlm.nih.gov/pubmed/26558346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9923
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi