Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases

Inosine-5′-monophosphate dehydrogenase (IMPDH) plays key roles in purine nucleotide metabolism and cell proliferation. Although IMPDH is a widely studied therapeutic target, there is limited information about its physiological regulation. Using Ashbya gossypii as a model, we describe the molecular m...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Buey, Rubén M., Ledesma-Amaro, Rodrigo, Velázquez-Campoy, Adrián, Balsera, Mónica, Chagoyen, Mónica, de Pereda, José M., Revuelta, José L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660370/
https://ncbi.nlm.nih.gov/pubmed/26558346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9923
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