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A Hyperactive Form of unc-13 Enhances Ca(2+) Sensitivity and Synaptic Vesicle Release Probability in C. elegans

Munc13 proteins play several roles in regulating shortterm synaptic plasticity. However, the underlying molecular mechanisms remain largely unclear. Here we report that C. elegans UNC-13L, a Munc13-1 ortholog, has three domains that inhibit synaptic vesicle (SV) exocytosis. These include the X (sequ...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Li, Lei, Liu, Haowen, Hall, Qi, Wang, Wei, Yu, Yi, Kaplan, Joshua M., Hu, Zhitao
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779330/
https://ncbi.nlm.nih.gov/pubmed/31509756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.018
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