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A Hyperactive Form of unc-13 Enhances Ca(2+) Sensitivity and Synaptic Vesicle Release Probability in C. elegans

Munc13 proteins play several roles in regulating shortterm synaptic plasticity. However, the underlying molecular mechanisms remain largely unclear. Here we report that C. elegans UNC-13L, a Munc13-1 ortholog, has three domains that inhibit synaptic vesicle (SV) exocytosis. These include the X (sequ...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Li, Lei, Liu, Haowen, Hall, Qi, Wang, Wei, Yu, Yi, Kaplan, Joshua M., Hu, Zhitao
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779330/
https://ncbi.nlm.nih.gov/pubmed/31509756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.018
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