Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans

UNC-13 proteins play an essential role in synaptic transmission by recruiting synaptic vesicles (SVs) to become available for release, which is termed SV priming. Here we show that the C2A domain of UNC-13L, like the corresponding domain in mammalian Munc13-1, displays two conserved binding modes: f...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Liu, Haowen, Li, Lei, Nedelcu, Daniel, Hall, Qi, Zhou, Lijun, Wang, Wei, Yu, Yi, Kaplan, Joshua M, Hu, Zhitao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2019
Onderwerpen:
Neuroscience
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6389284/
https://ncbi.nlm.nih.gov/pubmed/30802206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40585
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items