Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans

UNC-13 proteins play an essential role in synaptic transmission by recruiting synaptic vesicles (SVs) to become available for release, which is termed SV priming. Here we show that the C2A domain of UNC-13L, like the corresponding domain in mammalian Munc13-1, displays two conserved binding modes: f...

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Bibliographic Details
Published in:eLife
Main Authors: Liu, Haowen, Li, Lei, Nedelcu, Daniel, Hall, Qi, Zhou, Lijun, Wang, Wei, Yu, Yi, Kaplan, Joshua M, Hu, Zhitao
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2019
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6389284/
https://ncbi.nlm.nih.gov/pubmed/30802206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40585
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