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Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans
UNC-13 proteins play an essential role in synaptic transmission by recruiting synaptic vesicles (SVs) to become available for release, which is termed SV priming. Here we show that the C2A domain of UNC-13L, like the corresponding domain in mammalian Munc13-1, displays two conserved binding modes: f...
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| Publicado en: | eLife |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6389284/ https://ncbi.nlm.nih.gov/pubmed/30802206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40585 |
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