Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans

UNC-13 proteins play an essential role in synaptic transmission by recruiting synaptic vesicles (SVs) to become available for release, which is termed SV priming. Here we show that the C2A domain of UNC-13L, like the corresponding domain in mammalian Munc13-1, displays two conserved binding modes: f...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Liu, Haowen, Li, Lei, Nedelcu, Daniel, Hall, Qi, Zhou, Lijun, Wang, Wei, Yu, Yi, Kaplan, Joshua M, Hu, Zhitao
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2019
Pynciau:
Neuroscience
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6389284/
https://ncbi.nlm.nih.gov/pubmed/30802206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40585
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