UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans

Munc18-1/UNC-18 is believed to prime SNARE-mediated membrane fusion, yet the underlying mechanisms remain enigmatic. Here, we examine how potential gain-of-function mutations of Munc18-1/UNC-18 affect locomotory behavior and synaptic transmission, and how Munc18-1-mediated priming is related to Munc...

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Pubblicato in:J Neurosci
Autori principali: Park, Seungmee, Bin, Na-Ryum, Yu, Bin, Wong, Raymond, Sitarska, Ewa, Sugita, Kyoko, Ma, Ke, Xu, Junjie, Tien, Chi-Wei, Algouneh, Arash, Turlova, Ekaterina, Wang, Siyan, Siriya, Pranay, Shahid, Waleed, Kalia, Lorraine, Feng, Zhong-Ping, Monnier, Philippe P., Sun, Hong-Shuo, Zhen, Mei, Gao, Shangbang, Rizo, Josep, Sugita, Shuzo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2017
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588468/
https://ncbi.nlm.nih.gov/pubmed/28821673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0338-17.2017
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