Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion

Munc18-1 orchestrates SNARE complex assembly together with Munc13-1 to mediate neurotransmitter release. Munc18-1 binds to synaptobrevin, but the relevance of this interaction and its relation to Munc13 function are unclear. NMR experiments now show that Munc18-1 binds specifically and non-specifica...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Sitarska, Ewa, Xu, Junjie, Park, Seungmee, Liu, Xiaoxia, Quade, Bradley, Stepien, Karolina, Sugita, Kyoko, Brautigam, Chad A, Sugita, Shuzo, Rizo, Josep
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464772/
https://ncbi.nlm.nih.gov/pubmed/28477408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24278
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