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Re‐examining how Munc13‐1 facilitates opening of syntaxin‐1
Munc13‐1 is crucial for neurotransmitter release and, together with Munc18‐1, orchestrates assembly of the neuronal SNARE complex formed by syntaxin‐1, SNAP‐25, and synaptobrevin. Assembly starts with syntaxin‐1 folded into a self‐inhibited closed conformation that binds to Munc18‐1. Munc13‐1 is bel...
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| Publicado no: | Protein Sci |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7255523/ https://ncbi.nlm.nih.gov/pubmed/32086964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3844 |
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