Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans

Assembly of SNARE complexes that mediate neurotransmitter release requires opening of a ‘closed’ conformation of UNC-64/syntaxin. Rescue of unc-13/Munc13 mutant phenotypes by overexpressed open UNC-64/syntaxin suggested a specific function of UNC-13/Munc13 in opening UNC-64/ syntaxin. Here, we revis...

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Publicado no:Nat Commun
Main Authors: Tien, Chi-Wei, Yu, Bin, Huang, Mengjia, Stepien, Karolina P., Sugita, Kyoko, Xie, Xiaoyu, Han, Liping, Monnier, Philippe P., Zhen, Mei, Rizo, Josep, Gao, Shangbang, Sugita, Shuzo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606450/
https://ncbi.nlm.nih.gov/pubmed/33139696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19178-x
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