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Quantitative Studies of Muscleblind Proteins and Their Interaction With TCF4 RNA Foci Support Involvement in the Mechanism of Fuchs' Dystrophy

PURPOSE: Fuchs' endothelial corneal dystrophy (FECD) is a major cause of vision loss and the most common nucleotide repeat disorder, affecting 4% of United States population greater than 40 years of age. Seventy percent of FECD cases are due to an intronic CTG expansion within the TCF4 gene, re...

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Publicado en:Invest Ophthalmol Vis Sci
Main Authors: Rong, Ziye, Hu, Jiaxin, Corey, David R., Mootha, V. Vinod
Formato: Artigo
Idioma:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779288/
https://ncbi.nlm.nih.gov/pubmed/31560764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.19-27641
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