TCF4 Triplet Repeat Expansion and Nuclear RNA Foci in Fuchs' Endothelial Corneal Dystrophy

PURPOSE. Expansion of the intronic CTG18.1 triplet repeat locus within TCF4 contributes significant risk to the development of Fuchs' endothelial corneal dystrophy (FECD) in Eurasian populations, but the mechanisms by which the expanded repeats result in degeneration of the endothelium have bee...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Mootha, V. Vinod, Hussain, Imran, Cunnusamy, Khrishen, Graham, Eric, Gong, Xin, Neelam, Sudha, Xing, Chao, Kittler, Ralf, Petroll, W. Matthew
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373545/
https://ncbi.nlm.nih.gov/pubmed/25722209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-16222
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