Structural comparison of protiated, H/D-exchanged and deuterated human carbonic anhydrase IX

Human carbonic anhydrase IX (CA IX) expression is upregulated in hypoxic solid tumours, promoting cell survival and metastasis. This observation has made CA IX a target for the development of CA isoform-selective inhibitors. To enable structural studies of CA IX–inhibitor complexes using X-ray and n...

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Bibliographic Details
Published in:Acta Crystallogr D Struct Biol
Main Authors: Koruza, K., Lafumat, B., Nyblom, M., Mahon, B. P., Knecht, W., McKenna, R., Fisher, S. Z.
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2019
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778848/
https://ncbi.nlm.nih.gov/pubmed/31588921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798319010027
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