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Structural comparison of protiated, H/D-exchanged and deuterated human carbonic anhydrase IX
Human carbonic anhydrase IX (CA IX) expression is upregulated in hypoxic solid tumours, promoting cell survival and metastasis. This observation has made CA IX a target for the development of CA isoform-selective inhibitors. To enable structural studies of CA IX–inhibitor complexes using X-ray and n...
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| Publicado no: | Acta Crystallogr D Struct Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6778848/ https://ncbi.nlm.nih.gov/pubmed/31588921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798319010027 |
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