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A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca(2+)-activated Cl(−) channel ANO1 (TMEM16A)

ANO1 (TMEM16A) is a Ca(2+)-activated Cl(−) channel that regulates diverse cellular functions including fluid secretion, neuronal excitability, and smooth muscle contraction. ANO1 is activated by elevation of cytosolic Ca(2+) and modulated by phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)]. Here,...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Yu, Kuai, Jiang, Tao, Cui, YuanYuan, Tajkhorshid, Emad, Hartzell, H. Criss
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2019
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778221/
https://ncbi.nlm.nih.gov/pubmed/31515451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904012116
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