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A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca(2+)-activated Cl(−) channel ANO1 (TMEM16A)
ANO1 (TMEM16A) is a Ca(2+)-activated Cl(−) channel that regulates diverse cellular functions including fluid secretion, neuronal excitability, and smooth muscle contraction. ANO1 is activated by elevation of cytosolic Ca(2+) and modulated by phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)]. Here,...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6778221/ https://ncbi.nlm.nih.gov/pubmed/31515451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904012116 |
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