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An autoregulatory cell cycle timer integrates growth and specification in chick wing digit development

A fundamental question is how proliferation and growth are timed during embryogenesis. Although it has been suggested that the cell cycle could be a timer, the underlying mechanisms remain elusive. Here we describe a cell cycle timer that operates in Sonic hedgehog (Shh)-expressing polarising region...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Pickering, Joseph, Chinnaiya, Kavitha, Towers, Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777937/
https://ncbi.nlm.nih.gov/pubmed/31545166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47625
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