Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer’s disease

Hippocampal lesions are a defining pathology of Alzheimer’s disease (AD). However, the molecular mechanisms that underlie hippocampal synaptic injury in AD have not been fully elucidated. Current therapeutic efforts for AD treatment are not effective in correcting hippocampal synaptic deficits. Grow...

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Vydáno v:Sci Transl Med
Hlavní autoři: Tian, Jing, Guo, Lan, Sui, Shaomei, Driskill, Christopher, Phensy, Aarron, Wang, Qi, Gauba, Esha, Zigman, Jeffrey M., Swerdlow, Russell H., Kroener, Sven, Du, Heng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776822/
https://ncbi.nlm.nih.gov/pubmed/31413143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav6278
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