Pre-conceptional maternal exposure to cyclophosphamide results in modifications of DNA methylation in F1 and F2 mouse oocytes: evidence for transgenerational effects

Cyclophosphamide (CPM), an agent widely used in breast cancer therapy, has strong gonadotoxic effects. Female reproductive potential after therapy relies on ovulated oocytes deriving from primordial follicles surviving CPM toxic insult. In this study, we investigated in the mouse model whether pre-c...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Epigenetics
Egile Nagusiak: Di Emidio, Giovanna, D’Aurora, Marco, Placidi, Martina, Franchi, Sara, Rossi, Giulia, Stuppia, Liborio, Artini, Paolo Giovanni, Tatone, Carla, Gatta, Valentina
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2019
Gaiak:
Brief Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773401/
https://ncbi.nlm.nih.gov/pubmed/31189412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2019.1631111
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