Pre-conceptional maternal exposure to cyclophosphamide results in modifications of DNA methylation in F1 and F2 mouse oocytes: evidence for transgenerational effects

Cyclophosphamide (CPM), an agent widely used in breast cancer therapy, has strong gonadotoxic effects. Female reproductive potential after therapy relies on ovulated oocytes deriving from primordial follicles surviving CPM toxic insult. In this study, we investigated in the mouse model whether pre-c...

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Библиографические подробности
Опубликовано в: :Epigenetics
Главные авторы: Di Emidio, Giovanna, D’Aurora, Marco, Placidi, Martina, Franchi, Sara, Rossi, Giulia, Stuppia, Liborio, Artini, Paolo Giovanni, Tatone, Carla, Gatta, Valentina
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2019
Предметы:
Brief Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773401/
https://ncbi.nlm.nih.gov/pubmed/31189412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2019.1631111
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