Pre-conceptional maternal exposure to cyclophosphamide results in modifications of DNA methylation in F1 and F2 mouse oocytes: evidence for transgenerational effects

Cyclophosphamide (CPM), an agent widely used in breast cancer therapy, has strong gonadotoxic effects. Female reproductive potential after therapy relies on ovulated oocytes deriving from primordial follicles surviving CPM toxic insult. In this study, we investigated in the mouse model whether pre-c...

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Detalhes bibliográficos
Publicado no:Epigenetics
Main Authors: Di Emidio, Giovanna, D’Aurora, Marco, Placidi, Martina, Franchi, Sara, Rossi, Giulia, Stuppia, Liborio, Artini, Paolo Giovanni, Tatone, Carla, Gatta, Valentina
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773401/
https://ncbi.nlm.nih.gov/pubmed/31189412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2019.1631111
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