Pre-conceptional maternal exposure to cyclophosphamide results in modifications of DNA methylation in F1 and F2 mouse oocytes: evidence for transgenerational effects

Cyclophosphamide (CPM), an agent widely used in breast cancer therapy, has strong gonadotoxic effects. Female reproductive potential after therapy relies on ovulated oocytes deriving from primordial follicles surviving CPM toxic insult. In this study, we investigated in the mouse model whether pre-c...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Epigenetics
Main Authors: Di Emidio, Giovanna, D’Aurora, Marco, Placidi, Martina, Franchi, Sara, Rossi, Giulia, Stuppia, Liborio, Artini, Paolo Giovanni, Tatone, Carla, Gatta, Valentina
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2019
Assuntos:
Brief Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773401/
https://ncbi.nlm.nih.gov/pubmed/31189412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2019.1631111
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares