Pre-conceptional maternal exposure to cyclophosphamide results in modifications of DNA methylation in F1 and F2 mouse oocytes: evidence for transgenerational effects

Cyclophosphamide (CPM), an agent widely used in breast cancer therapy, has strong gonadotoxic effects. Female reproductive potential after therapy relies on ovulated oocytes deriving from primordial follicles surviving CPM toxic insult. In this study, we investigated in the mouse model whether pre-c...

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Dades bibliogràfiques
Publicat a:Epigenetics
Autors principals: Di Emidio, Giovanna, D’Aurora, Marco, Placidi, Martina, Franchi, Sara, Rossi, Giulia, Stuppia, Liborio, Artini, Paolo Giovanni, Tatone, Carla, Gatta, Valentina
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2019
Matèries:
Brief Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773401/
https://ncbi.nlm.nih.gov/pubmed/31189412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2019.1631111
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