Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme

Progressive cerebral accumulation of amyloid β-protein (Aβ) is an early and invariant feature of Alzheimer's disease. Little is known about how Aβ, after being secreted, is degraded and cleared from the extracellular space of the brain. Defective Aβ degradation could be a risk factor for the de...

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Bibliografske podrobnosti
izdano v:J Neurosci
Main Authors: Vekrellis, Konstantinos, Ye, Zhen, Qiu, Wei Qiao, Walsh, Dominic, Hartley, Dean, Chesneau, Valérie, Rosner, Marsha Rich, Selkoe, Dennis J.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2000
Teme:
ARTICLE
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772918/
https://ncbi.nlm.nih.gov/pubmed/10684867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-05-01657.2000
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