Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme

Progressive cerebral accumulation of amyloid β-protein (Aβ) is an early and invariant feature of Alzheimer's disease. Little is known about how Aβ, after being secreted, is degraded and cleared from the extracellular space of the brain. Defective Aβ degradation could be a risk factor for the de...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Vekrellis, Konstantinos, Ye, Zhen, Qiu, Wei Qiao, Walsh, Dominic, Hartley, Dean, Chesneau, Valérie, Rosner, Marsha Rich, Selkoe, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772918/
https://ncbi.nlm.nih.gov/pubmed/10684867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-05-01657.2000
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