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Amyloid β-Protein Is Degraded by Cellular Angiotensin-converting Enzyme (ACE) and Elevated by an ACE Inhibitor
Human genetic data have associated angiotensin-converting enzyme (ACE) with Alzheimer disease (AD), and purified ACE has been reported to cleave synthetic amyloid β-protein (Aβ) in vitro. Whether deficiency in ACE activity, arising from genetic alteration or pharmacological inhibition, can decrease...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2409196/ https://ncbi.nlm.nih.gov/pubmed/16154999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M508460200 |
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