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Genetic Inactivation of the Serotonin(1A) Receptor in Mice Results in Downregulation of Major GABA(A) Receptor α Subunits, Reduction of GABA(A) Receptor Binding, and Benzodiazepine-Resistant Anxiety

Anxiety is a common psychiatric illness often treated by benzodiazepines (BZs). BZs, such as Valium, bind to the α subunit of the pentameric GABA(A) receptor and increase inhibition in the CNS. There is considerable evidence for abnormal GABA(A)receptor function in anxiety, and a significant proport...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Sibille, Etienne, Pavlides, Constantine, Benke, Dietmar, Toth, Miklos
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772213/
https://ncbi.nlm.nih.gov/pubmed/10751426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-08-02758.2000
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