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Genetic Inactivation of the Serotonin(1A) Receptor in Mice Results in Downregulation of Major GABA(A) Receptor α Subunits, Reduction of GABA(A) Receptor Binding, and Benzodiazepine-Resistant Anxiety
Anxiety is a common psychiatric illness often treated by benzodiazepines (BZs). BZs, such as Valium, bind to the α subunit of the pentameric GABA(A) receptor and increase inhibition in the CNS. There is considerable evidence for abnormal GABA(A)receptor function in anxiety, and a significant proport...
Shranjeno v:
| izdano v: | J Neurosci |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Society for Neuroscience
2000
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6772213/ https://ncbi.nlm.nih.gov/pubmed/10751426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-08-02758.2000 |
| Oznake: |
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