Genetic Inactivation of the Serotonin(1A) Receptor in Mice Results in Downregulation of Major GABA(A) Receptor α Subunits, Reduction of GABA(A) Receptor Binding, and Benzodiazepine-Resistant Anxiety

Anxiety is a common psychiatric illness often treated by benzodiazepines (BZs). BZs, such as Valium, bind to the α subunit of the pentameric GABA(A) receptor and increase inhibition in the CNS. There is considerable evidence for abnormal GABA(A)receptor function in anxiety, and a significant proport...

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Vydáno v:J Neurosci
Hlavní autoři: Sibille, Etienne, Pavlides, Constantine, Benke, Dietmar, Toth, Miklos
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2000
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772213/
https://ncbi.nlm.nih.gov/pubmed/10751426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-08-02758.2000
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