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Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors

General methods to prepare chiral N‐heterocyclic molecular scaffolds are greatly sought after because of their significance in medicinal chemistry. Described here is the first general catalytic methodology to access a wide variety of chiral 2‐ and 4‐substituted tetrahydro‐quinolones, dihydro‐4‐pyrid...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Guo, Yafei, Harutyunyan, Syuzanna R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772156/
https://ncbi.nlm.nih.gov/pubmed/31257687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201906237
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