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Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors

General methods to prepare chiral N‐heterocyclic molecular scaffolds are greatly sought after because of their significance in medicinal chemistry. Described here is the first general catalytic methodology to access a wide variety of chiral 2‐ and 4‐substituted tetrahydro‐quinolones, dihydro‐4‐pyrid...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Guo, Yafei, Harutyunyan, Syuzanna R.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772156/
https://ncbi.nlm.nih.gov/pubmed/31257687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201906237
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