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Catalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines

α-Chiral amines are of significant importance in medicinal chemistry, asymmetric synthesis and material science, but methods for their efficient synthesis are scarce. In particular, the synthesis of α-chiral amines with the challenging tetrasubstituted carbon stereocentre is a long-standing problem...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Rong, Jiawei, Collados, Juan F., Ortiz, Pablo, Jumde, Ravindra P., Otten, Edwin, Harutyunyan, Syuzanna R.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5196062/
https://ncbi.nlm.nih.gov/pubmed/28008909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13780
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