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Enantioselective Catalytic Dearomative Addition of Grignard Reagents to 4-Methoxypyridinium Ions
[Image: see text] We describe a general catalytic methodology for the enantioselective dearomative alkylation of pyridine derivatives with Grignard reagents, allowing direct access to nearly enantiopure chiral dihydro-4-pyridones with yields up to 98%. The methodology involves dearomatization of in...
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| Publicado en: | ACS Catal |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Chemical Society
2021
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8291581/ https://ncbi.nlm.nih.gov/pubmed/34306813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.1c01544 |
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