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Highly enantioselective catalytic synthesis of chiral pyridines

General methods to prepare chiral pyridine derivatives are greatly sought after due to their significance in medicinal chemistry. Here, we report highly enantioselective catalytic transformations of poorly reactive β-substituted alkenyl pyridines to access a wide range of alkylated chiral pyridines....

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Bibliographic Details
Published in:Nat Commun
Main Authors: Jumde, Ravindra P., Lanza, Francesco, Pellegrini, Tilde, Harutyunyan, Syuzanna R.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727103/
https://ncbi.nlm.nih.gov/pubmed/29233959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01966-7
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