Collaboration of MYC and RUNX2 in lymphoma simulates T‐cell receptor signaling and attenuates p53 pathway activity

MYC and RUNX oncogenes each trigger p53‐mediated failsafe responses when overexpressed in vitro and collaborate with p53 deficiency in vivo. However, together they drive rapid onset lymphoma without mutational loss of p53. This phenomenon was investigated further by transcriptomic analysis of premal...

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Veröffentlicht in:J Cell Biochem
Hauptverfasser: Hay, Jodie, Gilroy, Kathryn, Huser, Camille, Kilbey, Anna, Mcdonald, Alma, MacCallum, Amanda, Holroyd, Ailsa, Cameron, Ewan, Neil, James C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772115/
https://ncbi.nlm.nih.gov/pubmed/31257681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.29143
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