Collaboration of MYC and RUNX2 in lymphoma simulates T‐cell receptor signaling and attenuates p53 pathway activity

MYC and RUNX oncogenes each trigger p53‐mediated failsafe responses when overexpressed in vitro and collaborate with p53 deficiency in vivo. However, together they drive rapid onset lymphoma without mutational loss of p53. This phenomenon was investigated further by transcriptomic analysis of premal...

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Pubblicato in:J Cell Biochem
Autori principali: Hay, Jodie, Gilroy, Kathryn, Huser, Camille, Kilbey, Anna, Mcdonald, Alma, MacCallum, Amanda, Holroyd, Ailsa, Cameron, Ewan, Neil, James C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772115/
https://ncbi.nlm.nih.gov/pubmed/31257681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.29143
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