RUNX‐mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins

RUNX gene over‐expression inhibits growth of primary cells but transforms cells with tumor suppressor defects, consistent with reported associations with tumor progression. In contrast, chromosomal translocations involving RUNX1 are detectable in utero, suggesting an initiating role in leukemias. Ho...

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Detalhes bibliográficos
Publicado no:J Cell Biochem
Main Authors: Anderson, Gail, Mackay, Nancy, Gilroy, Kathryn, Hay, Jodie, Borland, Gillian, McDonald, Alma, Bell, Margaret, Hassanudin, Siti Ayuni, Cameron, Ewan, Neil, James C., Kilbey, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813226/
https://ncbi.nlm.nih.gov/pubmed/29052866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.26443
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