Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model

The Runx genes function as dominant oncogenes that collaborate potently with Myc or loss of p53 to induce lymphoma when over-expressed. Here we examined the requirement for basal Runx1 activity for tumor maintenance in the Eμ-Myc model of Burkitt's lymphoma. While normal Runx1(fl/fl) lymphoid c...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Borland, Gillian, Kilbey, Anna, Hay, Jodie, Gilroy, Kathryn, Terry, Anne, Mackay, Nancy, Bell, Margaret, McDonald, Alma, Mills, Ken, Cameron, Ewan, Neil, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029604/
https://ncbi.nlm.nih.gov/pubmed/27056890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8554
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