RUNX1 and its fusion oncoprotein derivative RUNX1-ETO induce senescence-like growth arrest independently of replicative stress

A role for the RUNX genes in cancer failsafe processes has been suggested by their induction of senescence-like growth arrest in primary murine fibroblasts and the failure of RAS-induced senescence in Runx2 deficient cells. We now show that RUNX1 induces senescence in human primary fibroblasts. High...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Wolyniec, Kamil, Wotton, Sandy, Kilbey, Anna, Jenkins, Alma, Terry, Anne, Peters, Gordon, Stocking, Carol, Cameron, Ewan, Neil, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847638/
https://ncbi.nlm.nih.gov/pubmed/19448675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.101
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