RUNX1 and its fusion oncoprotein derivative RUNX1-ETO induce senescence-like growth arrest independently of replicative stress

A role for the RUNX genes in cancer failsafe processes has been suggested by their induction of senescence-like growth arrest in primary murine fibroblasts and the failure of RAS-induced senescence in Runx2 deficient cells. We now show that RUNX1 induces senescence in human primary fibroblasts. High...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Oncogene
Главные авторы: Wolyniec, Kamil, Wotton, Sandy, Kilbey, Anna, Jenkins, Alma, Terry, Anne, Peters, Gordon, Stocking, Carol, Cameron, Ewan, Neil, James C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847638/
https://ncbi.nlm.nih.gov/pubmed/19448675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.101
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы