An alternative transcript of the Alzheimer’s disease risk gene SORL1 encodes a truncated receptor

SORL1encodes a 250-kDa protein named sorLA, a functional sorting receptor for the amyloid precursor protein (APP). Several single nucleotide polymorphisms of the gene SORL1, encoding sorLA, are genetically associated with Alzheimer’s disease (AD). In the existing literature, SORL1 is insufficiently...

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Pubblicato in:Neurobiol Aging
Autori principali: Blechingberg, Jenny, Poulsen, Annemarie Svane Aavild, Kjølby, Mads, Monti, Giulia, Allen, Mariet, Ivarsen, Anne Kathrine, Lincoln, Sarah J., Thotakura, Gangadaar, Vægter, Christian B., Ertekin-Taner, Nilüfer, Nykjær, Anders, Andersen, Olav M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769419/
https://ncbi.nlm.nih.gov/pubmed/30078640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.06.021
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