An alternative transcript of the Alzheimer’s disease risk gene SORL1 encodes a truncated receptor

SORL1encodes a 250-kDa protein named sorLA, a functional sorting receptor for the amyloid precursor protein (APP). Several single nucleotide polymorphisms of the gene SORL1, encoding sorLA, are genetically associated with Alzheimer’s disease (AD). In the existing literature, SORL1 is insufficiently...

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Détails bibliographiques
Publié dans:Neurobiol Aging
Auteurs principaux: Blechingberg, Jenny, Poulsen, Annemarie Svane Aavild, Kjølby, Mads, Monti, Giulia, Allen, Mariet, Ivarsen, Anne Kathrine, Lincoln, Sarah J., Thotakura, Gangadaar, Vægter, Christian B., Ertekin-Taner, Nilüfer, Nykjær, Anders, Andersen, Olav M.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769419/
https://ncbi.nlm.nih.gov/pubmed/30078640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.06.021
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