Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury

Drug-induced liver injury (DILI) is a major concern for the pharmaceutical industry and constitutes one of the most important reasons for the termination of promising drug development projects. Reliable prediction of DILI liability in preclinical stages is difficult, as current experimental model sy...

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Vydáno v:Front Pharmacol
Hlavní autoři: Zhou, Yitian, Shen, Joanne X., Lauschke, Volker M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769037/
https://ncbi.nlm.nih.gov/pubmed/31616302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01093
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