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Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury

Drug-induced liver injury (DILI) is a major concern for the pharmaceutical industry and constitutes one of the most important reasons for the termination of promising drug development projects. Reliable prediction of DILI liability in preclinical stages is difficult, as current experimental model sy...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Zhou, Yitian, Shen, Joanne X., Lauschke, Volker M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769037/
https://ncbi.nlm.nih.gov/pubmed/31616302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01093
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