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Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury

Drug-induced liver injury (DILI) is a major concern for the pharmaceutical industry and constitutes one of the most important reasons for the termination of promising drug development projects. Reliable prediction of DILI liability in preclinical stages is difficult, as current experimental model sy...

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Publicat a:Front Pharmacol
Autors principals: Zhou, Yitian, Shen, Joanne X., Lauschke, Volker M.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769037/
https://ncbi.nlm.nih.gov/pubmed/31616302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01093
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