A Secreted Phospholipase A(2) Induces Formation of Smooth Muscle Foam Cells Which Transdifferentiate to Macrophage-Like State

Vascular smooth muscle cells (VSMCs) loaded with lipid droplets (LDs) are markers of atherosclerosis. In this disease, inflammatory Group IIA-secreted phospholipase A(2)s (GIIA sPLA(2)s) are highly expressed in VSMCs, but their actions in these cells are unknown. Here, we investigated the ability of...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Giannotti, Karina Cristina, Weinert, Sönke, Viana, Mariana Nascimento, Leiguez, Elbio, Araujo, Thaís L. S., Laurindo, Francisco R. M., Lomonte, Bruno, Braun-Dullaeus, Rüdiger, Teixeira, Catarina
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766822/
https://ncbi.nlm.nih.gov/pubmed/31489892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24183244
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