Critical Role of TLR2 and MyD88 for Functional Response of Macrophages to a Group IIA-Secreted Phospholipase A(2) from Snake Venom

The snake venom MT-III is a group IIA secreted phospholipase A(2) (sPLA(2)) enzyme with functional and structural similarities with mammalian pro-inflammatory sPLA(2)s of the same group. Previously, we demonstrated that MT-III directly activates the innate inflammatory response of macrophages, inclu...

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Detalhes bibliográficos
Main Authors: Leiguez, Elbio, Giannotti, Karina Cristina, Moreira, Vanessa, Matsubara, Márcio Hideki, Gutiérrez, José María, Lomonte, Bruno, Rodríguez, Juan Pablo, Balsinde, Jesús, Teixeira, Catarina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981733/
https://ncbi.nlm.nih.gov/pubmed/24718259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093741
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